• Salivation side effect of clozapine (sialorrhea)

• Sedation side effect of clozapine

• Myocarditis side effect of clozapine

• Constipation side effect of clozapine

• How do I interpret clozapine or norclozapine blood, serum or plasma levels; What do these mean?

• Clozapine blood count monitoring

• Seizure side effect of clozapine

• When to use clozapine

• Orthostatic hypotension due to clozapine

• Tachycardia side effect of clozapine

• How does one dose or titrate clozapine dosage when starting on this medication?

• Is weight gain a problem with clozapine, and what can be done?

• How does clozapine work and how is it different from other medications?

• Why is clozapine not the first medication chosen to treat schizophrenia for everyone?

• What is clozapine REMS?

• Clozapine Underutilization: Addressing the Barriers

• The Clozapine Risk Evaluation and Mitigation Strategy (REMS) Program Modification

• Vision side effects of clozapine

• What can I do if it is difficult or risky to start a patient on clozapine? Should patients be started on clozapine in the hospital?

• Should I be concerned if eosinophils are low or high with clozapine or there is eosinophilia?

• What are the issues regarding families and caregivers supporting clozapine treatment?

• Are there any contraindications or reasons a patient cannot be considered for clozapine? Can a patient with myocarditis or severe neutropenia be rechallenged and take clozapine again?

• What is Benign Ethnic Neutropenia and does it relate to low clozapine white counts?

• What should be done if the clozapine treatment of a patient is interrupted, or they do not take their clozapine for a few days or longer?

• What can clinicians do when individuals have either a partial or no response to clozapine?

• Is there anything I should know about smoking, tobacco or nicotine and clozapine?

• Have any patient tracking forms been developed for clozapine?

• A patient is moving to a new location and needs to find a new prescriber or pharmacist for clozapine. What information is available on this?

• What are the issues regarding starting clozapine in a patient with structural heart disease, such as cardiomyopathy or cardiac valve disease?

• What metabolic monitoring is appropriate when patients are taking clozapine? Should we monitor weight, labs or vital signs?

• What drug-drug medication interactions are important when starting or prescribing clozapine?

• What should I consider if a clozapine or norclozapine blood, plasma or serum level is surprisingly high?

• How do I start a clozapine clinic or system, or start to prescribe clozapine?

• Are there newer technologies, such as point of care (POC) tests or finger stick blood tests, that can help ease the monitoring burden and facilitate management of clozapine?

• How should I transition, taper or discontinue an existing antipsychotic medication when starting clozapine?

• Can botulinum toxin (Botox) be used for salivation caused by clozapine?

• What can cause blood or serum levels of clozapine to change or vary on a given dosage?

• Clozapine for Schizophrenia: A Comparison of the States

• Clozapine Center of Excellence

• Is clozapine more effective than other antipsychotic medications in individuals with treatment-resistant psychosis?

• What should be done if hepatic liver function tests are increased with clozapine treatment?

• What is known about use of clozapine for schizophrenia in children and adolescents (people younger than 18 years old)?

• Are there examples of monitoring protocols or tracking log forms that could be used when starting clozapine?

• What if a patient has clozapine side effects and is found to have a surprisingly high clozapine level?

• Is it possible to use fluvoxamine to improve the tolerability or metabolic side effects of clozapine?

• Can clozapine cause Obsessive Compulsive Disorder (OCD), and what can be done about this?

• What can be done if a patient taking clozapine is travelling to a foreign country?

• What should be considered regarding concurrent psychiatric medications, medications a patient is taking while considering or starting clozapine?

• What is known about norclozapine blood levels for patients taking clozapine?

• Is it possible to plan for continuation of clozapine during emergencies (such as coronavirus COVID-19 pandemic, infectious disease, hurricanes, tornadoes, earthquakes, rioting) that destroy infrastructure or limit travel, or other issues that prevent a patient from coming to a clinic or laboratory for necessary assessments or blood monitoring?

• During the COVID-19 pandemic, can pharmacies dispense clozapine without an absolute neutrophil count (ANC) blood test result?

• Can clozapine cause problems with urine or urination, such as incontinence (enuresis) or urinary retention?

• Can clozapine cause priapism, and if so what can be done?

• Is there an association between clozapine and venous thromboembolism?

• Does clozapine have a protective effect for suicide in people with schizophrenia or schizoaffective disorder?

• Is clozapine safe to continue during breastfeeding?

• Clozapine & LAI Virtual Forum – December 2020 (Video) – Pharmacologic and psychosocial strategies for a partial Clozapine response

• Clozapine & LAI Virtual Forum – April 2021 (Video) – Clozapine and Sialorrhea

• Clozapine & LAI Virtual Forum – June 2021 (Video) – Clozapine and treatment of cardiometabolic side effects

• Clozapine & LAI Virtual Forum – August 2021 (Video) – Case Study: Clozapine and Cognition

• Comparative Effectiveness of Antipsychotics for Risk of Attempted or Completed Suicide Among Persons With Schizophrenia

• Ask About Clozapine – Patient Handout

• Clozapine & LAI Virtual Forum – October 2021 (Video) – Keeping up with Clozapine REMS changes

• Clozapine REMS Program Updates: A Guide for Prescribers and Pharmacists

• Clozapine Monitoring Protocol

• Clozapine & LAI Virtual Forum – December 2021 (Video) – Initial impressions of Clozapine REMS: Troubleshooting and brainstorming new workflows

• A Survey of Personnel and Services Offered in 32 Outpatient US Clozapine Clinics

• Talking to Individuals and Families About Clozapine

• How do you present clozapine to a person who might benefit from it?

• Recommendations for Managing Patients on Pimozide, Lurasidone, or Clozapine During Treatment with a 5-Day Course of Paxlovid

• Can clozapine cause cardiomyopathy?

• Clozapine & LAI Virtual Forum – March 2022 (Video) – Continued troubleshooting on Clozapine REMS: Minimizing treatment disruptions and optimizing workflows

• Clozapine & LAI Virtual Forum – June 2022 (Video) – Benign Ethnic Neutropenia (BEN)

• Is there a relationship between long-term clozapine use and hematological malignancies?

• Vigilance and Monitoring for Clozapine Toxicity During COVID-19 Infection and Recommendations for Management

• Clozapine & LAI Virtual Forum – September 2022 (Video) – Appropriate use of weight loss medication with clozapine with a focus on GLP-1 agonists

• Clozapine & LAI Virtual Forum – November 2022 (Video) – Management of clozapine-induced constipation

• FDA exercises additional enforcement discretion for Clozapine REMS (Updated November 2, 2022)

• Clozapine & LAI Virtual Forum – January 2023 (Video) – OCD in patients taking clozapine

• Clozapine & LAI Virtual Forum – March 2023 (Video) – Managing Sedation Due to Clozapine

• Clozapine & LAI Virtual Forum – May 2023 (Video) – Management of Clozapine-Induced Sialorrhea: Highlighting Botulinum Toxin

• Clozapine & LAI Virtual Forum – August 2023 (Video) – Non-antipsychotic, pharmacologic augmentation strategies to partial responders on clozapine

• Is there only one best titration standard for starting clozapine?

• Is clozapine a medication that should only be used when all other medications have failed?

• First-line Treatments for Clozapine-induced Drooling (Videos & Handouts)

• Clozapine & LAI Virtual Forum – January 2024 (Video) – Clozapine’s Unique Role for Managing Aggressive Behavior

• Clozapine & LAI Virtual Forum – March 2024 (Video) – Debating the Use of Clozapine with Fluvoxamine